San Francisco has a lot of players on their injury report, but the biggest is Patrick Willis. The 49ers will hope the defense can play well without him, and hope that the secondary holds up. On the other side of the ball the Broncos have to be elated with their injury report.
Quarterbacks are breaking records left and right in the pass-happy NFL, but that makes high-caliber running backs all the more valuable. Many of last season’s top performers appear on this list, but keep in mind there’s usually a major bust or two, likely due to the heavy workload of the position causing a hangover effect.
While these two teams did play each other during pre-season, it’s safe to say that only a fool would look at that game footage in August for an inside edge.